This paper presents results of experience with simulation and measurement systems applied to local wind and hybrid (wind-diesel) isolated systems in south Patagonia, especially in Santa Cruz and Chubut provinces (Argentina) and the XII Region of Magallanes in Chile. Wind resource evaluation with a network of automatic loggers is discussed. Performance measurements include an integrated power curve evaluation system for small wind turbines. Some of the power, energy (early so-called SISMED systems) and commercial wind measurement systems have been operating in the region since 1999 or earlier, and their data provides important insight regarding best practices for sizing criteria in local wind and climate regimes. The data collected has been of value for validating simulations using NREL’s free HOMER software. The more recent Small Wind Turbine – Power Curve Evaluation System (SWT-PCES) addresses the special requirements involved in power curve measurement for small wind turbines, and has been deployed for very low-power isolated systems in Chubut province (Argentina). Data and operational aspects from systems installed are shown and discussed.